Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26364694 | 0.92 | PREP (0.51) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL4972525 | 0.86 | PREP (0.52) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL26364677 | 0.80 | PREP (0.59) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL489615 | 0.79 | PREP (0.62) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL10756717 | 0.79 | PREP (0.62) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL10756725 | 0.79 | PREP (0.62) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL28472467 | 0.79 | PREP (0.55) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL10937154 | 0.79 | KMT2A (0.55) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL4387236 | 0.78 | PREP (0.54) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL4389258 | 0.78 | PREP (0.53) | PREPNPSR1TSHRL3MBTL1CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303510-A1 | CYCLIZED ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. | 2023-09-28 | — | — | US | disclosed |
| US-20230303510-A1 | CYCLIZED ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. | 2023-09-28 | — | — | US | disclosed |
| EP-4188918-A1 | CYCLIZED ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2023-06-07 | — | — | EP | disclosed |
| WO-2022026565-A9 | CYCLIZED ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-12-08 | — | — | WO | disclosed |
| WO-2022026565-A1 | CYCLIZED ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303510-A1 | CYCLIZED ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | POLQ, POLB, POLH | PREP 1602/4885NPSR1 4835/4885TSHR 4202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.