Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KLK7 | P49862 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10937154 | 0.82 | KMT2A (0.55) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL7527978 | 0.81 | PREP (0.61) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL14496355 | 0.81 | PREP (0.65) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL10773451 | 0.81 | PREP (0.64) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL475715 | 0.81 | PREP (0.67) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL29553 | 0.81 | PREP (0.67) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL205223 | 0.81 | PREP (0.67) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL29658848 | 0.81 | PREP (0.67) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL16272917 | 0.80 | FKBP1A (0.66) | PREPNPSR1TSHRL3MBTL1CTRB1 | |
| SCHEMBL7326760 | 0.80 | FKBP1A (0.66) | PREPNPSR1TSHRL3MBTL1CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111801333-A | 10- (di (phenyl) methyl) -4-hydroxy-8, 9,9a, 10-tetrahydro-7H-pyrrolo [1',2':4,5] pyrazino [1,2-b ] pyridazine-3, 5-dione derivatives and related compounds as inhibitors of orthomyxovirus replication for the treatment of influenza | 诺华股份有限公司 | 2020-10-20 | — | — | CN | disclosed |