Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 9/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18839443 | 0.86 | DGAT1 (0.47) | FPR2DGAT1APLNRALDH1A1L3MBTL1 | |
| SCHEMBL16963923 | 0.83 | CES2 (0.46) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL16744658 | 0.82 | HTT (0.39) | FPR2AKR1C3AKR1C2MAPTAKR1C1 | |
| SCHEMBL8169224 | 0.82 | HTT (0.39) | FPR2AKR1C3AKR1C2MAPTAKR1C1 | |
| SCHEMBL1357313 | 0.82 | HTT (0.39) | FPR2AKR1C3AKR1C2MAPTAKR1C1 | |
| SCHEMBL19200334 | 0.82 | AKR1C3 (0.50) | AKR1C3AKR1C2ALDH1A1AKR1C1AKR1B10 | |
| SCHEMBL28108225 | 0.81 | DGAT1 (0.39) | FPR2DGAT1APLNRALDH1A1POLB | |
| SCHEMBL2383322 | 0.81 | TSHR (0.40) | AKR1C3AKR1C2ALDH1A1AKR1C1LMNA | |
| SCHEMBL1589867 | 0.81 | AKR1C3 (0.46) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL28397136 | 0.80 | AKR1C3 (0.46) | FPR2AKR1C3AKR1C2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569309-A1 | HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES | Bayer Intellectual Property GmbH (DE) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141325-A1 | HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-17 | — | — | WO | disclosed |