Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | RORB | Q92753 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637889 | 0.91 | KMT2A (0.46) | KMT2AMAPTALDH1A1GLAGRM5 | |
| SCHEMBL2637499 | 0.89 | KMT2A (0.44) | KMT2AMAPTALDH1A1GLAGRM5 | |
| SCHEMBL2638375 | 0.86 | MAPT (0.48) | KMT2AMAPTALDH1A1GRM5NPC1 | |
| SCHEMBL2637478 | 0.84 | HSP90AA1 (0.47) | KMT2AMAPTALDH1A1GRM5NPC1 | |
| SCHEMBL2637509 | 0.82 | HSP90AA1 (0.44) | KMT2AMAPTNPC1RAB9AMEN1 | |
| SCHEMBL2637406 | 0.78 | MAPT (0.41) | KMT2AMAPTALDH1A1GRM5NPC1 | |
| SCHEMBL2637595 | 0.76 | MAPT (0.43) | KMT2AMAPTGRM5NPC1RAB9A | |
| SCHEMBL2637972 | 0.75 | MEN1 (0.41) | KMT2AMAPTALDH1A1GLANPC1 | |
| SCHEMBL2637795 | 0.75 | MEN1 (0.44) | KMT2AMAPTALDH1A1GLANPC1 | |
| SCHEMBL2637207 | 0.74 | CNR2 (0.45) | KMT2AMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |