Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PSD | A5PKW4 | 2/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637343 | 0.90 | ALDH1A1 (0.46) | HSP90AA1HSP90AB1NPC1RAB9APOLB | |
| SCHEMBL2637556 | 0.89 | POLB (0.46) | HSP90AA1HSP90AB1NPC1RAB9APOLB | |
| SCHEMBL2637716 | 0.87 | KMT2A (0.47) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL2638375 | 0.86 | MAPT (0.48) | NPC1RAB9ATDP1ALDH1A1GRM5 | |
| SCHEMBL2637509 | 0.86 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1NPC1RAB9AKDM4A | |
| SCHEMBL2637331 | 0.84 | KMT2A (0.47) | NPC1RAB9APOLBKCNK3KCNK9 | |
| SCHEMBL2637972 | 0.83 | MEN1 (0.41) | NPC1RAB9AKDM4AKDM5AKDM4C | |
| SCHEMBL2637207 | 0.81 | CNR2 (0.45) | NPC1RAB9APOLBKCNK3KCNK9 | |
| SCHEMBL2637448 | 0.79 | NPC1 (0.46) | NPC1RAB9APOLBKCNK3KCNK9 | |
| SCHEMBL2637740 | 0.79 | KDM5A (0.41) | NPC1RAB9ATDP1KDM5AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | claimed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | claimed |
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |