Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PNLIP | P16233 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637331 | 0.91 | KMT2A (0.47) | KMT2AALDH1A1MAPTGLAKDM4E | |
| SCHEMBL2637499 | 0.91 | KMT2A (0.44) | KMT2AALDH1A1MAPTGLAKDM4E | |
| SCHEMBL2637595 | 0.85 | MAPT (0.43) | KMT2AMAPTKCNMA1LMNAPNLIP | |
| SCHEMBL2637556 | 0.83 | POLB (0.46) | KMT2AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL2637406 | 0.78 | MAPT (0.41) | KMT2AALDH1A1MAPTKDM4EKCNMA1 | |
| SCHEMBL2637547 | 0.77 | NPC1 (0.48) | KMT2AMAPTLMNANPC1RAB9A | |
| SCHEMBL2638375 | 0.76 | MAPT (0.48) | KMT2AALDH1A1MAPTKCNMA1LMNA | |
| SCHEMBL2637343 | 0.75 | ALDH1A1 (0.46) | KMT2AALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL2637590 | 0.74 | KDM4E (0.41) | KMT2AALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL2637478 | 0.73 | HSP90AA1 (0.47) | KMT2AALDH1A1MAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |