Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637406 | 0.92 | MAPT (0.41) | MAPTRAB9ASMN1; SMN2ALDH1A1KCNMA1 | |
| SCHEMBL2637595 | 0.90 | MAPT (0.43) | MAPTRAB9ASMN1; SMN2KCNMA1NPC1 | |
| SCHEMBL2637547 | 0.90 | NPC1 (0.48) | MAPTRAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL2637478 | 0.86 | HSP90AA1 (0.47) | MAPTRAB9AALDH1A1NPC1DHODH | |
| SCHEMBL2637331 | 0.86 | KMT2A (0.47) | MAPTRAB9AALDH1A1KCNMA1NPC1 | |
| SCHEMBL2637509 | 0.83 | HSP90AA1 (0.44) | MAPTRAB9ANPC1TP53MEN1 | |
| SCHEMBL2637972 | 0.77 | MEN1 (0.41) | MAPTRAB9AALDH1A1NPC1LMNA | |
| SCHEMBL2637889 | 0.76 | KMT2A (0.46) | MAPTRAB9AALDH1A1KCNMA1NPC1 | |
| SCHEMBL2637207 | 0.76 | CNR2 (0.45) | MAPTRAB9AALDH1A1NPC1DHODH | |
| SCHEMBL2637343 | 0.76 | ALDH1A1 (0.46) | MAPTRAB9ASMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |