Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 8/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | GOT1 | P17174 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637737 | 0.83 | NPC1 (0.43) | NPC1RAB9A | |
| SCHEMBL2637403 | 0.82 | MEN1 (0.47) | MEN1NPC1KMT2A | |
| SCHEMBL2637207 | 0.81 | CNR2 (0.45) | MAPK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2637450 | 0.79 | MEN1 (0.38) | MAPK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2637827 | 0.79 | NPC1 (0.54) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2637506 | 0.78 | MEN1 (0.40) | JAK2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2637249 | 0.77 | SMN1; SMN2 (0.50) | MAPK1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2637260 | 0.77 | CNR2 (0.50) | JAK2JAK1TYK2MEN1NPC1 | |
| SCHEMBL2637448 | 0.77 | NPC1 (0.46) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL2637533 | 0.76 | MAPT (0.50) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | claimed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | claimed |
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |