Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637588 | 0.87 | KMT2A (0.45) | MAPTKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL3409988 | 0.78 | MAPT (0.53) | MAPTKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL3413627 | 0.75 | MAPT (0.46) | MAPTKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL2637547 | 0.72 | NPC1 (0.48) | MAPTKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL2637595 | 0.69 | MAPT (0.43) | MAPTKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL2637406 | 0.69 | MAPT (0.41) | MAPTKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL2638375 | 0.68 | MAPT (0.48) | MAPTKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL27785087 | 0.65 | MEN1 (0.50) | MAPTKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL15410721 | 0.64 | MEN1 (0.56) | MAPTKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL3409206 | 0.63 | MAPT (0.47) | MAPTKMT2AMEN1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |