Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637595 | 0.92 | MAPT (0.43) | NPC1RAB9AGRM5MAPTSMN1; SMN2 | |
| SCHEMBL2638375 | 0.90 | MAPT (0.48) | NPC1RAB9AGRM5MAPTSMN1; SMN2 | |
| SCHEMBL2637406 | 0.90 | MAPT (0.41) | NPC1RAB9AGRM5MAPTSMN1; SMN2 | |
| SCHEMBL2637343 | 0.85 | ALDH1A1 (0.46) | NPC1RAB9AGRM5MAPTSMN1; SMN2 | |
| SCHEMBL2637580 | 0.80 | GRM5 (0.44) | GRM5LMNAMEN1KMT2ATDP1 | |
| SCHEMBL2637740 | 0.80 | KDM5A (0.41) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2637556 | 0.78 | POLB (0.46) | NPC1RAB9AMAPTSMN1; SMN2LMNA | |
| SCHEMBL2637889 | 0.77 | KMT2A (0.46) | NPC1RAB9AGRM5MAPTLMNA | |
| SCHEMBL2637478 | 0.77 | HSP90AA1 (0.47) | NPC1RAB9AGRM5MAPTLMNA | |
| SCHEMBL3409988 | 0.76 | MAPT (0.53) | NPC1MAPTSMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | claimed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | claimed |
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |