Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407406 | 0.83 | BRD4 (0.46) | MAPTPKMNPC1AURKAAURKB | |
| SCHEMBL3413627 | 0.78 | MAPT (0.46) | MAPTLMNANPC1TP53GAA | |
| SCHEMBL2637575 | 0.78 | MAPT (0.40) | MAPTLMNAPKMNPC1TP53 | |
| SCHEMBL3413639 | 0.78 | MEN1 (0.47) | MAPTNPC1TP53GAAKMT2A | |
| SCHEMBL3407740 | 0.77 | NPC1 (0.49) | MAPTLMNAPKMNPC1TP53 | |
| SCHEMBL2637547 | 0.76 | NPC1 (0.48) | MAPTLMNAPKMNPC1TP53 | |
| SCHEMBL2637406 | 0.75 | MAPT (0.41) | MAPTLMNAPKMNPC1TP53 | |
| SCHEMBL2637595 | 0.75 | MAPT (0.43) | MAPTLMNAPKMNPC1TP53 | |
| SCHEMBL3411555 | 0.74 | ALDH1A1 (0.46) | MAPTLMNANPC1GAAAURKA | |
| SCHEMBL2638375 | 0.73 | MAPT (0.48) | MAPTLMNAPKMNPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | claimed |
| EP-2264035-A1 | Glycine B antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-22 | — | — | EP | disclosed |