Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640983 | 0.89 | ALDH1A1 (0.47) | SMN1; SMN2TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL2637260 | 0.85 | CNR2 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4A | |
| SCHEMBL2637450 | 0.85 | MEN1 (0.38) | MEN1KMT2AKDM4AKDM5AKDM4C | |
| SCHEMBL2637207 | 0.83 | CNR2 (0.45) | MEN1KMT2AALDH1A1KDM4AKDM5A | |
| SCHEMBL2637531 | 0.83 | NPC1 (0.44) | SMN1; SMN2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2637763 | 0.83 | ALDH1A1 (0.51) | SMN1; SMN2TSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL2637448 | 0.81 | NPC1 (0.46) | MEN1KMT2AKDM4AKDM5AKDM4C | |
| SCHEMBL2637493 | 0.80 | NHERF1 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL2637533 | 0.80 | MAPT (0.50) | TSHRMEN1KMT2ALMNA | |
| SCHEMBL2637188 | 0.80 | MGAM (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | claimed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | claimed |
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |