Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20325180 | 0.98 | PAOX (0.44) | PAOXTHRATHRBRAB9AALDH1A1 | |
| SCHEMBL21421662 | 0.92 | PAOX (0.46) | PAOXTHRATHRBRAB9AALDH1A1 | |
| SCHEMBL24787986 | 0.86 | PRMT5 (0.42) | PAOXRAB9AALDH1A1POLBKMT2A | |
| SCHEMBL21907165 | 0.83 | HRH3 (0.47) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL20230963 | 0.82 | PAOX (0.44) | PAOXTHRATHRBRAB9AALDH1A1 | |
| SCHEMBL22266239 | 0.81 | MEN1 (0.43) | RAB9AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22266186 | 0.81 | HRH3 (0.50) | ALDH1A1MEN1KMT2AHRH3 | |
| SCHEMBL22266180 | 0.81 | L3MBTL1 (0.50) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL20230967 | 0.80 | PRMT5 (0.43) | PAOXRAB9AALDH1A1KDM4EPOLB | |
| SCHEMBL19634433 | 0.80 | GNAI3 (0.53) | PAOXTHRATHRBRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-B1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS INC (US) | 2023-09-27 | — | — | EP | disclosed |