Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 3/20 | 0.53 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.53 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23471047 | 0.98 | GNAI3 (0.50) | GNAI3GNAO1GNAI1HPGDNPC1 | |
| SCHEMBL21348422 | 0.96 | GNAI3 (0.53) | GNAI3GNAO1GNAI1HPGDNPC1 | |
| SCHEMBL23205258 | 0.96 | GNAI3 (0.49) | GNAI3GNAO1GNAI1HPGDNPC1 | |
| SCHEMBL6553947 | 0.94 | GNAI3 (0.53) | GNAI3GNAO1GNAI1HPGDNPC1 | |
| SCHEMBL4902016 | 0.92 | GNAI3 (0.47) | GNAI3GNAO1GNAI1HPGDNPC1 | |
| Bromide SCHEMBL28255534 | 0.92 | GNAI3 (0.52) | GNAI3GNAO1GNAI1HPGDNPC1 | |
| SCHEMBL11570760 | 0.90 | GNAI3 (0.53) | GNAI3GNAO1GNAI1HPGDNPC1 | |
| SCHEMBL20325468 | 0.88 | ALDH1A1 (0.49) | GNAI3GNAO1GNAI1HPGDRAB9A | |
| SCHEMBL19604922 | 0.88 | GNAI3 (0.47) | GNAI3GNAO1GNAI1HPGDNPC1 | |
| SCHEMBL21106252 | 0.88 | GNAI3 (0.47) | GNAI3GNAO1GNAI1LTA4HTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3831841-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T Global Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2019-07-02 | — | — | US | disclosed |
| US-20180179176-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2018-06-28 | — | — | US | disclosed |
| WO-2017200984-A1 | NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF | S&T GLOBAL INC. (US) | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | MIF, MMP12, CSF1R | GNAI3 112/4885GNAO1 1401/4885GNAI1 262/4885 |
| US-20180179176-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | MIF, MMP12, CSF1R | GNAI3 112/4885GNAO1 1401/4885GNAI1 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.