Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.45 |
| ▸ | RXRB | P28702 | 5/20 | 0.45 |
| ▸ | RXRG | P48443 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2871094 | 0.87 | RXRA (0.48) | RXRARXRBRXRGALDH1A1HDAC1 | |
| SCHEMBL2638950 | 0.85 | KMO (0.54) | RXRARXRBRXRGALDH1A1HDAC1 | |
| SCHEMBL31604686 | 0.85 | KMO (0.54) | RXRARXRBRXRGALDH1A1HDAC1 | |
| SCHEMBL2871079 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HDAC1HDAC8HDAC6PTPN1 | |
| SCHEMBL628795 | 0.78 | RXRA (0.49) | RXRARXRBRXRGS1PR1 | |
| SCHEMBL19182234 | 0.76 | RXRA (0.58) | RXRARXRBRXRGALDH1A1KMO | |
| SCHEMBL4872369 | 0.76 | KMO (0.55) | ALDH1A1HDAC1HDAC8HDAC6KMO | |
| SCHEMBL22892178 | 0.76 | NOTUM (0.51) | ALDH1A1HDAC1HDAC8HDAC6PTPN1 | |
| SCHEMBL16899143 | 0.76 | PDE4B (0.48) | ALDH1A1HDAC1HDAC8HDAC6PTPN1 | |
| SCHEMBL12521280 | 0.76 | HDAC1 (0.49) | RXRARXRBALDH1A1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307394-B1 | SULPHONAMIDES AS VANILLOID RECEPTOR ANTAGONIST | AMOREPACIFIC CORP (KR) | 2012-09-26 | — | — | EP | claimed |
| JP-2011526625-A | — | — | 2011-10-13 | — | — | JP | claimed |
| WO-2010002209-A2 | NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | AMOREPACIFIC CORPORATION (KR) | 2010-01-07 | — | — | WO | claimed |
| EP-2307394-B1 | SULPHONAMIDES AS VANILLOID RECEPTOR ANTAGONIST | AMOREPACIFIC CORP (KR) | 2012-09-26 | — | — | EP | disclosed |