Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RPS6KB2 | Q9UBS0 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2049950 | 0.81 | ALDH1A1 (0.39) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2053905 | 0.81 | LMNA (0.45) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2050825 | 0.80 | ADORA1 (0.44) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4834622 | 0.77 | LMNA (0.64) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2049985 | 0.77 | ALDH1A1 (0.41) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21854198 | 0.76 | ALDH1A1 (0.49) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3847403 | 0.73 | ALDH1A1 (0.36) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL26388364 | 0.69 | KMT2A (0.45) | ALDH1A1SMN1; SMN2MEN1KMT2AL3MBTL1 | |
| SCHEMBL16200382 | 0.69 | THRB (0.42) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9385111 | 0.68 | KMT2A (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |