SCHEMBL2639110

SCHEMBL2639110

Cc1cc(OCCCS(N)(=O)=O)ccc1NC(=O)Cc1ccc(Cl)c(Oc2cc(Cl)ccc2Br)c1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA12 O43570 7/20 0.42
CA1 P00915 7/20 0.42
CA2 P00918 7/20 0.42
CA9 Q16790 7/20 0.42
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
P2RX4 Q99571 3/20 0.37
ALDH1A1 P00352 2/20 0.36
GAA P10253 2/20 0.36
MAPT P10636 2/20 0.36
KDM4E B2RXH2 1/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
S1PR4 O95977 1/20 0.36
SETD1B Q9UPS6 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4602432 0.94 CA12 (0.42) CA12CA1CA2CA9MEN1
SCHEMBL2639837 0.82 SLC2A1 (0.40) CA12CA1CA2CA9SMN1; SMN2
SCHEMBL2638515 0.79 CA1 (0.58) CA12CA1CA2CA9
SCHEMBL2638624 0.75 CA1 (0.61) CA12CA1CA2CA9MEN1
SCHEMBL2638641 0.72 MEN1 (0.53) CA12CA1CA2CA9MEN1
SCHEMBL4602237 0.72 HPGD (0.48) MEN1KMT2AL3MBTL1SMN1; SMN2ALDH1A1
SCHEMBL2639161 0.72 CA2 (0.59) CA12CA1CA2CA9P2RX4
SCHEMBL5623913 0.69 SLC2A1 (0.56) L3MBTL1SMN1; SMN2ALDH1A1GAAMAPT
SCHEMBL3837659 0.69 CA1 (0.60) CA12CA1CA2CA9MEN1
SCHEMBL2638680 0.68 CA1 (0.52) CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4810529-B2 2011-11-09 JP claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP claimed
EP-1742908-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2007-01-17 EP claimed
WO-2005102989-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-11-03 WO claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP disclosed