SCHEMBL2639151

SCHEMBL2639151

CCc1ccc(CC(=O)Nc2ccccc2)cc1Oc1cc(C#N)cc(C#N)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.45
RORC P51449 7/20 0.43
SMN1; SMN2 Q16637 4/20 0.41
KMT2A Q03164 3/20 0.41
HTT P42858 2/20 0.41
BCHE P06276 2/20 0.41
ACHE P22303 2/20 0.41
ALDH1A1 P00352 3/20 0.39
HPGD P15428 2/20 0.39
MAPT P10636 2/20 0.39
NPSR1 Q6W5P4 2/20 0.39
HSD17B10 Q99714 2/20 0.39
KDM4E B2RXH2 1/20 0.39
POLB P06746 1/20 0.39
RXFP1 Q9HBX9 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
MEN1 O00255 2/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2639288 0.89 ALDH1A1 (0.44) RORCSMN1; SMN2KMT2AALDH1A1HPGD
SCHEMBL2638989 0.88 CA1 (0.48) LMNARORCSMN1; SMN2KMT2APOLB
SCHEMBL2638227 0.84 LMNA (0.46) LMNARORCSMN1; SMN2KMT2AHTT
SCHEMBL2638730 0.80 CA1 (0.52) RORC
SCHEMBL2639652 0.80 CA1 (0.43) RORC
SCHEMBL2638392 0.79 ALDH1A1 (0.43) RORCSMN1; SMN2KMT2AALDH1A1HPGD
SCHEMBL2639418 0.78 CA1 (0.47) LMNARORCSMN1; SMN2KMT2APOLB
SCHEMBL2638866 0.75 ALDH1A1 (0.47) RORCSMN1; SMN2KMT2AHTTALDH1A1
SCHEMBL2638078 0.75 LMNA (0.51) LMNARORCSMN1; SMN2KMT2ABCHE
SCHEMBL2638812 0.74 ALDH1A1 (0.45) LMNARORCSMN1; SMN2KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4810529-B2 2011-11-09 JP claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP claimed
EP-1742908-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2007-01-17 EP claimed
WO-2005102989-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-11-03 WO claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP disclosed