Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.49 |
| ▸ | JAK3 | P52333 | 6/20 | 0.49 |
| ▸ | PLK4 | O00444 | 5/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.49 |
| ▸ | CDK1 | P06493 | 5/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.49 |
| ▸ | TYK2 | P29597 | 5/20 | 0.49 |
| ▸ | CLK2 | P49760 | 5/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.49 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.49 |
| ▸ | MARK3 | P27448 | 3/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26394395 | 0.82 | MAP2K4 (0.55) | JAK2JAK3PLK4DAPK3CDK1 | |
| SCHEMBL26394712 | 0.77 | GSK3B (0.51) | JAK2JAK3PLK4DAPK3CDK1 | |
| SCHEMBL26393486 | 0.77 | HDAC6 (0.50) | JAK2JAK3TYK2GSK3BCCNC | |
| SCHEMBL7214763 | 0.76 | FADS1 (0.56) | GSK3BMAPK1CCNCCDK8FADS1 | |
| SCHEMBL26394241 | 0.76 | HDAC6 (0.48) | JAK2JAK3PLK4DAPK3CDK1 | |
| SCHEMBL13810908 | 0.76 | PDPK1 (0.54) | JAK2JAK3PLK4DYRK1AAURKB | |
| SCHEMBL12056341 | 0.75 | GRM4 (0.44) | JAK2JAK3PLK4CDK1CDK2 | |
| SCHEMBL26394420 | 0.75 | JAK2 (0.66) | JAK2JAK3PLK4DAPK3CDK1 | |
| SCHEMBL21656763 | 0.75 | GSK3B (0.44) | JAK2JAK3PLK4DAPK3CDK1 | |
| SCHEMBL4007120 | 0.75 | GSK3B (0.69) | JAK2ROCK2ROCK1GSK3BAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |