Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | MARK3 | P27448 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26394420 | 0.86 | JAK2 (0.66) | GSK3BGSK3AJAK2MKNK1JAK1 | |
| SCHEMBL26394366 | 0.82 | CYP1A2 (0.59) | GSK3BGSK3AJAK2JAK1TYK2 | |
| SCHEMBL26394484 | 0.77 | JAK2 (0.49) | GSK3BGSK3AJAK2MKNK1TYK2 | |
| SCHEMBL26393486 | 0.76 | HDAC6 (0.50) | GSK3BJAK2JAK1TYK2JAK3 | |
| SCHEMBL26394395 | 0.75 | MAP2K4 (0.55) | GSK3BGSK3AJAK2MKNK1TYK2 | |
| SCHEMBL26394241 | 0.75 | HDAC6 (0.48) | GSK3BGSK3AJAK2JAK1TYK2 | |
| SCHEMBL13810908 | 0.75 | PDPK1 (0.54) | GSK3BGSK3AJAK2MKNK1JAK3 | |
| SCHEMBL26395290 | 0.75 | NMT1 (0.50) | GSK3BGSK3ACDK2CLK4PIM1 | |
| SCHEMBL26394340 | 0.74 | GSK3B (0.47) | GSK3BGSK3AJAK2JAK1TYK2 | |
| SCHEMBL31032755 | 0.73 | TRPA1 (0.54) | CDK2FLT3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |