Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.66 |
| ▸ | JAK1 | P23458 | 1/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.66 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26394712 | 0.86 | GSK3B (0.51) | JAK2JAK1TYK2JAK3PAK1 | |
| SCHEMBL26393486 | 0.85 | HDAC6 (0.50) | JAK2JAK1TYK2JAK3PAK1 | |
| SCHEMBL26394241 | 0.84 | HDAC6 (0.48) | JAK2JAK1TYK2JAK3PAK1 | |
| SCHEMBL26393947 | 0.83 | JAK2 (0.61) | JAK2JAK1TYK2JAK3PAK1 | |
| SCHEMBL2660923 | 0.81 | JAK2 (0.62) | JAK2JAK1TYK2JAK3PAK1 | |
| SCHEMBL26394366 | 0.80 | CYP1A2 (0.59) | JAK2JAK1TYK2JAK3GSK3B | |
| SCHEMBL26396309 | 0.80 | LRRK2 (0.45) | JAK2JAK1TYK2JAK3PAK1 | |
| SCHEMBL26394340 | 0.80 | GSK3B (0.47) | JAK2JAK1TYK2JAK3PAK1 | |
| SCHEMBL2661697 | 0.80 | JAK2 (1.00) | JAK2JAK1TYK2JAK3PAK1 | |
| SCHEMBL26396737 | 0.79 | PIM1 (0.45) | JAK2JAK1TYK2JAK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |