SCHEMBL26399166

SCHEMBL26399166

N#C[C@]1(c2ccc3c(N)ncnn23)CC[C@@H](COC(=O)OCC2(c3ccccc3)CC2)O1

nearest known ligand 0.39

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26399191 0.88 AXL (0.32) —
SCHEMBL26399140 0.87 PIK3CD (0.33) PIK3CD
SCHEMBL26399290 0.86 PIK3CD (0.32) PIK3CD
SCHEMBL26399270 0.86 PIK3CD (0.32) PIK3CD
SCHEMBL24790990 0.84 TMPRSS2 (0.30) PIK3CD
SCHEMBL25608337 0.84 MGLL (0.38) —
SCHEMBL24789794 0.84 PIK3CD (0.34) PIK3CD
SCHEMBL26399178 0.83 TMPRSS2 (0.32) PIK3CD
SCHEMBL26399152 0.83 JAK2 (0.34) PIK3CD
SCHEMBL26320604 0.82 PIK3CD (0.31) PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11780844-B2 Compounds and methods for treatment of viral infections GILEAD SCIENCES, INC. (US) 2023-10-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11780844-B2 Compounds and methods for treatment of viral infections HAVCR2, EIF2AK2, OAT PIK3CD 4574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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