Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29487862 | 0.73 | CYP1A2 (0.49) | MAPTALDH1A1MEN1KMT2ADRD1 | |
| SCHEMBL18587481 | 0.71 | HTR2A (0.50) | MAPTALDH1A1DRD1HTR2AHTR2C | |
| SCHEMBL31175957 | 0.70 | CLK4 (0.42) | MAPTALDH1A1MEN1KMT2ADRD1 | |
| SCHEMBL4827059 | 0.67 | CYP1A2 (0.63) | MAPTALDH1A1MEN1KMT2ADRD1 | |
| SCHEMBL16911318 | 0.67 | S1PR1 (0.54) | MAPTALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL30880684 | 0.67 | CYP3A4 (0.43) | MAPTALDH1A1DRD1KDM4ENPC1 | |
| SCHEMBL3230291 | 0.67 | ALDH1A1 (0.54) | MAPTALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL30088705 | 0.66 | PDE10A (0.46) | MAPTALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL30122990 | 0.66 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL27002310 | 0.65 | ALDH1A1 (0.44) | MAPTALDH1A1KDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011529943-A | — | — | 2011-12-15 | — | — | JP | claimed |
| WO-2010015628-A1 | PYRAZOLO [5,1-B] OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | claimed |
| WO-2010015628-A1 | PYRAZOLO [5,1-B] OXAZOLE DERIVATIVES AS CRF1 ANTAGONISTS | NOVARTIS AG (CH) | 2010-02-11 | — | — | WO | disclosed |