Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 4/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | CRHBP | P24387 | 1/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14110759 | 0.85 | TSHR (1.00) | TSHRHPGDTDP1ALDH1A1KMT2A | |
| SCHEMBL23183510 | 0.85 | TSHR (0.80) | TSHRHPGDTDP1ALDH1A1KMT2A | |
| SCHEMBL20339938 | 0.83 | KDM4E (0.74) | TSHRHPGDTDP1ALDH1A1KMT2A | |
| SCHEMBL26404299 | 0.78 | MAPT (0.51) | TSHRHPGDTDP1ALDH1A1KMT2A | |
| SCHEMBL12818167 | 0.77 | ALDH1A1 (0.78) | TSHRHPGDTDP1ALDH1A1KMT2A | |
| SCHEMBL26403803 | 0.77 | TSHR (0.67) | TSHRHPGDTDP1ALDH1A1KMT2A | |
| SCHEMBL5312871 | 0.77 | KMT2A (1.00) | TSHRHPGDTDP1ALDH1A1KMT2A | |
| SCHEMBL32688189 | 0.77 | ALDH1A1 (0.53) | TSHRHPGDTDP1ALDH1A1KMT2A | |
| SCHEMBL26404209 | 0.75 | KDM4E (0.51) | TSHRHPGDTDP1ALDH1A1KMT2A | |
| SCHEMBL26404220 | 0.75 | MAPT (0.51) | TSHRHPGDTDP1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2023-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ALDH7A1, ACMSD, AMD1 | TSHR 4389/4885HPGD 311/4885TDP1 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.