Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640823 | 1.00 | HDAC7 (0.53) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 | |
| SCHEMBL11686163 | 0.95 | HDAC1 (0.59) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 | |
| SCHEMBL1286243 | 0.90 | ALDH1A1 (0.55) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 | |
| SCHEMBL1781793 | 0.90 | ALDH1A1 (0.55) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 | |
| SCHEMBL9219366 | 0.85 | MMP2 (0.55) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 | |
| SCHEMBL7898753 | 0.83 | HDAC7 (0.52) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 | |
| SCHEMBL9191639 | 0.83 | HDAC1 (0.52) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 | |
| SCHEMBL11093898 | 0.83 | HDAC1 (0.52) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 | |
| SCHEMBL3359985 | 0.83 | HDAC7 (0.52) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 | |
| SCHEMBL7026832 | 0.83 | HDAC1 (0.52) | HDAC7HDAC1MMP2MMP9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106905386-B | Aminoglycoside derivatives | 莱姆派克斯制药公司 | 2020-03-27 | — | — | CN | disclosed |
| EP-2569324-B9 | AMINOGLYCOSIDE DERIVATIVES | REMPEX PHARMACEUTICALS INC (US) | 2018-03-28 | — | — | EP | disclosed |
| EP-2569324-B1 | AMINOGLYCOSIDE DERIVATIVES | REMPEX PHARMACEUTICALS INC (US) | 2017-12-06 | — | — | EP | disclosed |
| US-8906868-B2 | Aminoglycoside derivatives | REMPEX PHARMACEUTICALS, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| CN-103003293-A | Aminoglycoside Derivatives | REMPEX PHARMACEUTICALS INC | 2013-03-27 | — | — | CN | disclosed |
| EP-2569324-A1 | AMINOGLYCOSIDE DERIVATIVES | Rempex Pharmaceuticals, Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| US-20130059808-A1 | AMINOGLYCOSIDE DERIVATIVES | REMPEX PHARMACEUTICALS, INC. (US) | 2013-03-07 | — | — | US | disclosed |
| WO-2011143497-A1 | AMINOGLYCOSIDE DERIVATIVES | REMPEX PHARMACEUTICALS, INC. (US) | 2011-11-17 | — | — | WO | disclosed |
| US-4104372-A | ANTIBACTERIAL | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1978-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059808-A1 | AMINOGLYCOSIDE DERIVATIVES | AMPD3, ALG8, MRPL21 | HDAC7 1220/4885HDAC1 1293/4885MMP2 3754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.