Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29112417 | 0.86 | TSHR (0.39) | HSD11B1TSHROPRM1OPRD1OPRK1 | |
| SCHEMBL30626434 | 0.86 | TSHR (0.39) | HSD11B1TSHROPRM1OPRD1OPRK1 | |
| SCHEMBL15513651 | 0.79 | ALDH1A1 (0.47) | HSD11B1TSHROPRM1OPRD1SMN1; SMN2 | |
| SCHEMBL27347345 | 0.79 | KMT2A (0.49) | HSD11B1TSHROPRM1OPRD1OPRK1 | |
| SCHEMBL1361875 | 0.79 | TSHR (0.58) | HSD11B1TSHROPRM1SMN1; SMN2KMT2A | |
| SCHEMBL2636427 | 0.78 | TSHR (0.38) | HSD11B1TSHR | |
| SCHEMBL4242183 | 0.73 | HSD11B1 (0.65) | HSD11B1TSHROPRM1 | |
| SCHEMBL9466435 | 0.73 | SLC6A4 (0.56) | HSD11B1TSHRCNR2 | |
| SCHEMBL4242554 | 0.73 | SMN1; SMN2 (0.54) | HSD11B1TSHRSMN1; SMN2 | |
| SCHEMBL627858 | 0.73 | HSD11B1 (0.60) | HSD11B1TSHROPRM1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768826-A1 | SUBSTITUTED OXADIAZOLYL PYRIDINONES AND OXADIAZOLYL PYRIDAZINONES AS HIF INHIBITORS | Bayer Intellectual Property GmbH (DE) | 2014-08-27 | — | — | EP | disclosed |
| WO-2013057101-A1 | SUBSTITUTED OXADIAZOLYL PYRIDINONES AND OXADIAZOLYL PYRIDAZINONES AS HIF INHIBITORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-04-25 | — | — | WO | disclosed |
| EP-2569309-A1 | HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES | Bayer Intellectual Property GmbH (DE) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141325-A1 | HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-17 | — | — | WO | disclosed |