SCHEMBL26409164

SCHEMBL26409164

O=C(CN1CC2(CCC(C(=O)NC34CCC(CC3)C4)CC2)C1)NC1(C(F)(F)F)CC1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.33
CACNA1H O95180 8/20 0.33
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26409158 0.93 CACNA1H (0.32) CACNA1H
SCHEMBL26409165 0.91 ALDH1A1 (0.43) ALDH1A1CACNA1HKDM4E
SCHEMBL26409689 0.75 CACNA1H (0.45) ALDH1A1CACNA1H
SCHEMBL26409928 0.73 CACNA1H (0.61) ALDH1A1CACNA1HKDM4E
SCHEMBL26408701 0.72 NPSR1 (0.49) ALDH1A1KDM4E
SCHEMBL26408044 0.72 CACNA1H (0.48) ALDH1A1CACNA1H
SCHEMBL26408705 0.72 NPSR1 (0.40) ALDH1A1CACNA1HKDM4E
SCHEMBL26408685 0.72 TP53 (0.44) ALDH1A1
SCHEMBL26408699 0.72 MALT1 (0.47) ALDH1A1CACNA1H
SCHEMBL26409172 0.68 CACNA1H (0.43) ALDH1A1CACNA1HKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023192675-A1 T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIRONONANE CORE AND METHODS OF USE THEREOF PRAXIS PRECISION MEDICINES, INC. (US) 2023-10-05 WO disclosed