SCHEMBL26409342

SCHEMBL26409342

N=C(C#Cc1cc2nc(C3CCC3)sc2cc1F)c1c(N)ncnc1N

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
UBE2M P61081 3/20 0.32
DCUN1D1 Q96GG9 3/20 0.32
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
GFER P55789 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26412060 0.96 UBE2M (0.33) UBE2MDCUN1D1ALDH1A1GAAGFER
SCHEMBL26409235 0.82 NPC1 (0.35) UBE2MDCUN1D1ALDH1A1GAAGFER
SCHEMBL26409184 0.78 RET (0.34)
SCHEMBL26412083 0.76 ILK (0.31)
SCHEMBL26411956 0.73 RET (0.38)
SCHEMBL24251984 0.72 NPC1 (0.36) UBE2MDCUN1D1ALDH1A1GAAGFER
SCHEMBL26409280 0.72 RET (0.34)
SCHEMBL26411818 0.70 FAAH (0.36)
SCHEMBL26408870 0.68
SCHEMBL30580483 0.68 FGFR2 (0.58)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4169922-A1 FGFR AND MUTATION INHIBITOR THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF Abbisko Therapeutics Co., Ltd. (CN) 2023-04-26 EP disclosed