7-Deazaguanine

7-Deazaguanine

SCHEMBL26412

Nc1nc2c(c(=O)[nH]1)CC=N2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 2/20 0.38
QTRT1 Q9BXR0 1/20 0.37
XDH P47989 2/20 0.37
TYMS P04818 2/20 0.36
DYRK1A Q13627 1/20 0.36
MAPT P10636 2/20 0.35
CDK1 P06493 1/20 0.35
CDK4 P11802 1/20 0.35
CDK2 P24941 1/20 0.35
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
HSD17B10 Q99714 2/20 0.35
THRB P10828 2/20 0.35
LMNA P02545 1/20 0.35
GLA P06280 1/20 0.35
PMP22 Q01453 1/20 0.35
MEN1 O00255 1/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 1/20 0.35
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
7-Deazaguanine SCHEMBL28090184 0.79 KDM4E (0.32) KDM4EALDH1A1HSD17B10LMNAGLA
7-Deazaguanine SCHEMBL28112182 0.78 PNP (0.40) PNPMAPTKDM4EALDH1A1HSD17B10
SCHEMBL31233486 0.78 PARP1 (0.41) TYMSMAPTKDM4EALDH1A1HSD17B10
SCHEMBL4237665 0.71 NOS1 (0.38) PNPQTRT1XDHDYRK1AHSD17B10
SCHEMBL8133897 0.68 NOS1 (0.33) PNPQTRT1XDHDYRK1AKDM4E
SCHEMBL535022 0.68 QTRT1 (0.42) PNPQTRT1XDHTYMSDYRK1A
SCHEMBL142922 0.68 QTRT1 (0.42) PNPQTRT1XDHTYMSDYRK1A
SCHEMBL29480634 0.68 PNP (0.39) PNPQTRT1TYMSDYRK1AMAPT
SCHEMBL12959072 0.64 XDH (0.45) PNPQTRT1XDHTYMS
SCHEMBL12481054 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 25444 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630827-B2 Antisense oligonucleotides targeting SCN2A for the treatment of SCN1A encephalopathies ROGCON, INC. (US) 2026-05-19 US claimed
CN-122029176-A Containing a plurality of oligonucleotides modified oligonucleotides 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122029177-A Oligonucleotides containing multiple ligands and/or lipids 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122028913-A Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions 阿达尔克斯制药有限公司 2026-05-12 CN claimed
EP-4234566-B1 MODIFIED NUCLEOSIDE OR NUCLEOTIDE BGI SHENZHEN (CN) 2026-04-15 EP claimed
EP-4717779-A2 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TriLink BioTechnologies, LLC (US) 2026-04-01 EP claimed
EP-4453243-B1 PERIODATE COMPOSITIONS AND METHODS FOR CHEMICAL CLEAVAGE OF SURFACE-BOUND POLYNUCLEOTIDES ILLUMINA INC (US) 2026-02-11 EP claimed
EP-4448786-B1 METHODS FOR METAL DIRECTED CLEAVAGE OF SURFACE-BOUND POLYNUCLEOTIDES ILLUMINA INC (US) 2026-02-04 EP claimed
US-12467080-B2 PNA oligomer, use thereof for detecting DNA methylation, and method for detecting DNA methylation using same SEASUNBIO MATERIALS (KR) 2025-11-11 US claimed
US-20250320496-A1 MODULATION OF ABCB11 GENE TRANSCRIPTION USING ANTISENSE OLIGONUCLEOTIDES TARGETING REGULATORY RNAS CAMP4 THERAPEUTICS CORPORATION 2025-10-16 US claimed
EP-0290583-B1 $g(a) OLIGONUCLEOTIDES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1993-04-07 EP claimed
EP-0418309-A4 OLIGONUCLEOTIDE ANALOGS CONTAINING SULFUR 1993-01-07 EP claimed
US-5142033-A Structure-independent DNA amplification by the polymerase chain reaction HOFFMANN-LA ROCHE INC. (US) 1992-08-25 US claimed
WO-1992013869-A1 METHYLENE PHOSPHONATE NUCLEOSIDE ANALOGS AND OLIGONUCLEOTIDE ANALOGS MADE THEREFROM GILEAD SCIENCES, INC. (US) 1992-08-20 WO claimed
EP-0431523-A2 Modified nucleotide compounds ENZO BIOCHEM, INC. (US) 1991-06-12 EP claimed
EP-0418309-A1 OLIGONUCLEOTIDE ANALOGS CONTAINING SULFUR BENNER, Steven Albert (CH) 1991-03-27 EP claimed
WO-1989012060-A1 OLIGONUCLEOTIDE ANALOGS CONTAINING SULFUR BENNER STEVEN ALBERT (CH) 1989-12-14 WO claimed
EP-0290583-A1 -g(a) OLIGONUCLEOTIDES. CENTRE NAT RECH SCIENT (FR) 1988-11-17 EP claimed
WO-1988004301-A1 alpha OLIGONUCLEOTIDES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) 1988-06-16 WO claimed
EP-0252683-A2 Process and reagents for DNA sequence analysis E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-01-13 EP claimed