Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26414162 | 0.91 | ALDH1A1 (0.33) | PLA2G2AKMT2AMEN1 | |
| SCHEMBL25934603 | 0.90 | PLA2G2A (0.38) | PLA2G2AKMT2ALMNAMEN1 | |
| SCHEMBL26020504 | 0.86 | MEN1 (0.32) | PLA2G2AKMT2AMEN1NPC1RAB9A | |
| SCHEMBL26412454 | 0.85 | NOTUM (0.33) | PLA2G2AKMT2AMEN1NPC1RAB9A | |
| SCHEMBL26412344 | 0.84 | PLA2G2A (0.31) | PLA2G2A | |
| SCHEMBL26412345 | 0.84 | CYP3A4 (0.31) | — | |
| SCHEMBL26412339 | 0.81 | HSD17B10 (0.34) | PLA2G2AEGFRMRGPRX4MAPTKMT2A | |
| SCHEMBL26415363 | 0.80 | PLA2G2A (0.39) | PLA2G2AEGFRMRGPRX4MAPTGAA | |
| SCHEMBL26412332 | 0.77 | LTB4R (0.33) | PLA2G2AMRGPRX4PTGER1KMT2A | |
| SCHEMBL24073863 | 0.76 | MEN1 (0.36) | PLA2G2AMAPTGAAKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230130109-A1 | MACROCYCLIC INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN PHARMACEUTICA NV (BE) | 2023-04-27 | — | — | US | disclosed |
| US-20230130109-A1 | MACROCYCLIC INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | JANSSEN PHARMACEUTICA NV (BE) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230130109-A1 | MACROCYCLIC INDOLE DERIVATIVES AS INHIBITORS OF MCL-1 | MCL1, BCL2L1, BAK1 | PLA2G2A 3383/4885EGFR 1698/4885MRGPRX4 4194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.