Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 1/20 | 0.59 |
| ▸ | ERN1 | O75460 | 1/20 | 0.59 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.59 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3660554 | 0.95 | L3MBTL1 (0.65) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL3658943 | 0.92 | NPC1 (0.60) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL6707186 | 0.90 | RAB9A (0.79) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL9265040 | 0.90 | RAB9A (0.79) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL19445791 | 0.85 | RAB9A (0.72) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL26400418 | 0.83 | KMT2A (0.61) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL7233864 | 0.83 | RAB9A (0.68) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL2310568 | 0.83 | RAB9A (0.68) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL613993 | 0.83 | RAB9A (0.68) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL21104744 | 0.83 | RAB9A (0.68) | RAB9ANPC1L3MBTL1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |