Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | GRM5 | P41594 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | MLLT1 | Q03111 | 2/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.56 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26413302 | 0.95 | RAB9A (0.70) | L3MBTL1RAB9ANPC1GRM5KDM4E | |
| SCHEMBL3658943 | 0.93 | NPC1 (0.60) | L3MBTL1RAB9ANPC1GRM5KDM4E | |
| SCHEMBL27748372 | 0.85 | L3MBTL1 (0.67) | L3MBTL1RAB9ANPC1GRM5KDM4E | |
| SCHEMBL9265040 | 0.84 | RAB9A (0.79) | L3MBTL1RAB9ANPC1GRM5KDM4E | |
| SCHEMBL6707186 | 0.84 | RAB9A (0.79) | L3MBTL1RAB9ANPC1GRM5KDM4E | |
| SCHEMBL18175978 | 0.82 | L3MBTL1 (0.63) | L3MBTL1RAB9ANPC1GRM5KDM4E | |
| SCHEMBL29818202 | 0.82 | L3MBTL1 (0.63) | L3MBTL1RAB9ANPC1GRM5KDM4E | |
| SCHEMBL10210732 | 0.82 | NPC1 (0.51) | L3MBTL1RAB9ANPC1GRM5KDM4E | |
| SCHEMBL27177195 | 0.81 | USP30 (0.56) | L3MBTL1RAB9ANPC1GRM5PKM | |
| SCHEMBL2316588 | 0.80 | NPC1 (0.68) | L3MBTL1RAB9ANPC1GRM5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234995-A1 | LEUKOTRIENE B4 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009077385-A1 | LEUKOTRIENE B4 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |