Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14614929 | 0.78 | PTGES (0.59) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL23629250 | 0.76 | PTPN11 (0.43) | CYP3A4GAA | |
| SCHEMBL15546999 | 0.74 | PTGES (0.50) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL15535597 | 0.74 | PTGES (0.50) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL2752539 | 0.73 | RAB9A (0.62) | KMT2AALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL28721012 | 0.73 | PTGES (0.48) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL23629251 | 0.73 | KDM5A (0.50) | — | |
| SCHEMBL23629273 | 0.71 | BTK (0.54) | KDM4EL3MBTL1 | |
| SCHEMBL26398154 | 0.71 | TNKS (0.52) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL22932654 | 0.71 | CD38 (0.71) | ALDH1A1KDM4ESMN1; SMN2PTGESLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |