Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15546999 | 1.00 | PTGES (0.50) | PTGESNPC1LMNAALDH1A1RAB9A | |
| SCHEMBL28721012 | 0.99 | PTGES (0.48) | PTGESNPC1LMNAALDH1A1RAB9A | |
| SCHEMBL14614929 | 0.83 | PTGES (0.59) | PTGESNPC1LMNAALDH1A1RAB9A | |
| SCHEMBL15548888 | 0.83 | CD38 (0.39) | PTGESBRD4 | |
| SCHEMBL26414255 | 0.74 | MEN1 (0.48) | PTGESNPC1LMNAALDH1A1RAB9A | |
| SCHEMBL7692327 | 0.72 | EGLN1 (0.57) | NPC1LMNAALDH1A1RAB9AHTT | |
| SCHEMBL7685902 | 0.72 | EGLN1 (0.57) | NPC1LMNAALDH1A1RAB9AHTT | |
| SCHEMBL28917070 | 0.72 | CDK2 (0.56) | PTGESCDK1CCNB1CCNA2CDK2 | |
| SCHEMBL6071453 | 0.72 | RAB9A (0.54) | PTGESNPC1LMNAALDH1A1RAB9A | |
| SCHEMBL29438449 | 0.71 | SMN1; SMN2 (0.51) | NPC1LMNAALDH1A1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458174-B2 | Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof | STEMERGIE BIOTECHNOLOGY SA (CH) | 2016-10-04 | — | — | US | claimed |
| US-20150148301-A1 | INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF | Stemergie Biotechnology SA a corporation | 2015-05-28 | — | — | US | claimed |
| EP-2852439-A1 | INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF | Stemergie Biotechnology SA (CH) | 2015-04-01 | — | — | EP | claimed |
| WO-2013174947-A1 | INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF | STEMERGIE BIOTECHNOLOGY SA (CH) | 2013-11-28 | — | — | WO | claimed |
| US-20200188361-A1 | USE OF MITOCHONDRIAL ACTIVITY INHIBITORS FOR THE TREATMENT OF POOR PROGNOSIS ACUTE MYELOID LEUKEMIA | UNIVERSITE DE MONTREAL (CA) | 2020-06-18 | — | — | US | disclosed |
| US-20190192488-A1 | USE OF MITOCHONDRIAL ACTIVITY INHIBITORS FOR THE TREATMENT OF POOR PROGNOSIS ACUTE MYELOID LEUKEMIA | Université de Montréal (CA) | 2019-06-27 | — | — | US | disclosed |
| US-9458174-B2 | Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof | STEMERGIE BIOTECHNOLOGY SA (CH) | 2016-10-04 | — | — | US | disclosed |
| US-9458174-B2 | Inhibitors of the activity of complex (III) of the mitochondrial electron transport chain and use thereof | STEMERGIE BIOTECHNOLOGY SA (CH) | 2016-10-04 | — | — | US | disclosed |
| US-20150148301-A1 | INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF | Stemergie Biotechnology SA a corporation | 2015-05-28 | — | — | US | disclosed |
| US-20150148301-A1 | INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF | Stemergie Biotechnology SA a corporation | 2015-05-28 | — | — | US | disclosed |
| EP-2852439-A1 | INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF | Stemergie Biotechnology SA (CH) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013174947-A1 | INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF | STEMERGIE BIOTECHNOLOGY SA (CH) | 2013-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200188361-A1 | USE OF MITOCHONDRIAL ACTIVITY INHIBITORS FOR THE TREATMENT OF POOR PROGNOSIS ACUTE MYELOID LEUKEMIA | NPM1, TFAM, NDUFAF1 | PTGES 4509/4885NPC1 2898/4885LMNA 837/4885 |
| US-20150148301-A1 | INHIBITORS OF THE ACTIVITY OF COMPLEX (III) OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF | NDUFB3, MT-CO3, SLC25A1 | PTGES 771/4885NPC1 825/4885LMNA 3569/4885 |
| US-20190192488-A1 | USE OF MITOCHONDRIAL ACTIVITY INHIBITORS FOR THE TREATMENT OF POOR PROGNOSIS ACUTE MYELOID LEUKEMIA | IDH2, TFAM, NUTF2 | PTGES 4605/4885NPC1 2667/4885LMNA 1148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.