Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | BRD4 | O60885 | 4/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | AKT2 | P31751 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3083270 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1BRD4BRD3CHEK1 | |
| SCHEMBL5259632 | 0.77 | S1PR1 (0.49) | KDM4EALDH1A1HSD17B10S1PR1 | |
| SCHEMBL27685100 | 0.77 | CHEK1 (0.53) | KDM4EALDH1A1BRD4CHEK1AKT2 | |
| SCHEMBL16209719 | 0.76 | AKT2 (0.79) | KDM4EALDH1A1BRD4BRD3CHEK1 | |
| SCHEMBL16005913 | 0.76 | ROCK2 (0.54) | KDM4EALDH1A1BRD4BRD3CHEK1 | |
| SCHEMBL24765276 | 0.74 | CHEK1 (0.59) | ALDH1A1CHEK1AKT2LMNAROCK2 | |
| SCHEMBL9440147 | 0.74 | ALDH1A1 (0.56) | ALDH1A1TSHRHSD17B10DHFRS1PR1 | |
| SCHEMBL4863136 | 0.73 | KDM4E (0.64) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL17117158 | 0.72 | ALDH1A1 (0.54) | ALDH1A1TSHRHSD17B10DHFRS1PR1 | |
| SCHEMBL21262737 | 0.71 | AKT2 (0.70) | ALDH1A1BRD4CHEK1AKT2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072962-A1 | SUBSTITUTED QUINOLINES AS IMPROVED NF-KB-INDUCING KINASE (NIK) INHIBITORS | Yukin Therapeutics (FR) | 2023-05-04 | — | — | WO | disclosed |
| EP-4169904-A1 | SUBSTITUTED QUINOLINES AS IMPROVED NF-KB-INDUCING KINASE (NIK) INHIBITORS | Yukin Therapeutics (FR) | 2023-04-26 | — | — | EP | disclosed |