Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | ALPL | P05186 | 2/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12088725 | 0.87 | KDM4E (0.55) | MAPTKDM4EGSK3BAAK1MAPK1 | |
| SCHEMBL10206036 | 0.81 | DDAH1 (0.59) | KDM4CDDAH1KRASHTT | |
| SCHEMBL19001265 | 0.80 | PKM (0.42) | KDM4EAAK1KDM4CMAPK1ALPL | |
| SCHEMBL9851482 | 0.78 | KDM4C (0.63) | KDM4EAAK1KDM4CDDAH1KMT2A | |
| SCHEMBL4072911 | 0.77 | CACNA1H (0.44) | KDM4CDDAH1KRAS | |
| SCHEMBL7578581 | 0.77 | KDM4C (0.40) | KDM4EKDM4CDDAH1KRASSMN1; SMN2 | |
| SCHEMBL31875233 | 0.77 | CACNA1H (0.44) | KDM4CDDAH1KRAS | |
| SCHEMBL5806722 | 0.77 | TDP1 (0.49) | KDM4CDDAH1KRASNPSR1TDP1 | |
| SCHEMBL4113303 | 0.77 | DDAH1 (0.65) | MAPTKDM4EMAPK1ALPLDDAH1 | |
| SCHEMBL11955037 | 0.77 | KDM4C (0.40) | AAK1KDM4CDDAH1CYP2C9KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675858-B1 | IMIDAZO[1,5-A]PYRAZINE COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | OPTIKIRA LLC (US) | 2023-04-26 | — | — | EP | disclosed |