Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566224 | 0.81 | PLK1 (0.50) | PLK1HDAC8HDAC6HDAC2DDB1 | |
| SCHEMBL2635589 | 0.81 | KDM4E (0.57) | KDM5AHTTTDP1LMNA | |
| SCHEMBL16572975 | 0.79 | PLK1 (0.49) | PLK1HDAC8HDAC6HDAC2DDB1 | |
| SCHEMBL7222069 | 0.79 | PLK1 (0.49) | PLK1HDAC8HDAC6HDAC2DDB1 | |
| SCHEMBL31082091 | 0.79 | TAS1R3 (0.55) | PLK1HDAC8HDAC6HDAC2DDB1 | |
| SCHEMBL5743063 | 0.79 | TAS1R3 (0.55) | PLK1HDAC8HDAC6HDAC2DDB1 | |
| SCHEMBL13702396 | 0.79 | TAS1R3 (0.55) | PLK1HDAC8HDAC6HDAC2DDB1 | |
| SCHEMBL22612088 | 0.79 | PLK1 (0.49) | PLK1HDAC8HDAC6HDAC2DDB1 | |
| SCHEMBL22627253 | 0.79 | PLK1 (0.49) | PLK1HDAC8HDAC6HDAC2DDB1 | |
| SCHEMBL12900868 | 0.79 | GABRP (0.61) | PLK1HDAC8HDAC6HDAC2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |