Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | TK2 | O00142 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12642442 | 1.00 | TK1 (0.41) | TK1LMNASMN1; SMN2ALOX12ADRA1A | |
| SCHEMBL658719 | 1.00 | TK1 (0.41) | TK1LMNASMN1; SMN2ALOX12ADRA1A | |
| SCHEMBL23892079 | 1.00 | TK1 (0.41) | TK1LMNASMN1; SMN2ALOX12ADRA1A | |
| SCHEMBL2888800 | 0.81 | TYMS (0.48) | — | |
| SCHEMBL31685733 | 0.79 | TK1 (0.32) | TK1LMNASMN1; SMN2 | |
| SCHEMBL346202 | 0.76 | POLA1 (0.42) | — | |
| 5-Bromouracil SCHEMBL4280022 | 0.76 | TK1 (0.40) | TK1LMNASMN1; SMN2ALOX12ADRA1A | |
| Fluorouracil SCHEMBL8778444 | 0.76 | LMNA (0.51) | TK1LMNASMN1; SMN2ALOX12ADRA1A | |
| SCHEMBL24420223 | 0.75 | TK1 (0.39) | TK1LMNASMN1; SMN2ALOX12ADRA1A | |
| SCHEMBL1675551 | 0.75 | TK1 (0.39) | TK1LMNASMN1; SMN2ALOX12ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011142798-A2 | METHODS OF PREPARING TARGETED APTAMER PRODRUGS | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2011-11-17 | — | — | WO | disclosed |