SCHEMBL26415980

SCHEMBL26415980

c1ccc(-c2nc(-c3ccccc3)nc(-c3cc(-c4ccc(-n5c6cc7ccccc7cc6c6cc7ccccc7cc65)cc4)cc4oc5ccccc5c34)n2)cc1

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 1/20 0.31
SIRT1 Q96EB6 1/20 0.31
TSHR P16473 2/20 0.31
LMNA P02545 2/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CCNC P24863 1/20 0.30
CDK8 P49336 1/20 0.30
POLB P06746 1/20 0.30
MAPT P10636 1/20 0.30
HTT P42858 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26415947 0.97 KDM4E (0.33) SIRT2SIRT1
SCHEMBL26415942 0.97 KDM4E (0.33) SIRT2SIRT1
SCHEMBL26416010 0.93 KDM4E (0.33) SIRT2SIRT1MAPT
SCHEMBL26416005 0.92 KDM4E (0.31)
SCHEMBL24151956 0.92 SMN1; SMN2 (0.34) SIRT2SIRT1TSHRLMNASMN1; SMN2
SCHEMBL22893713 0.90 SMN1; SMN2 (0.33) SIRT2SIRT1TSHRLMNASMN1; SMN2
SCHEMBL26416879 0.90 KDM4E (0.30) SMN1; SMN2KMT2A
SCHEMBL26416925 0.90 KDM4E (0.32) MAPT
SCHEMBL24154747 0.90 PLA2G2A (0.34) SIRT2SIRT1TSHRLMNASMN1; SMN2
SCHEMBL25051170 0.89 TSHR (0.33) SIRT2SIRT1TSHRLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230128360-A1 HETEROCYCLIC COMPOUND, ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME, COMPOSITION FOR ORGANIC LAYER OF ORGANIC LIGHT EMITTING DEVICE LT MATERIALS CO., LTD. (KR) 2023-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230128360-A1 HETEROCYCLIC COMPOUND, ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME, COMPOSITION FOR ORGANIC LAYER OF ORGANIC LIGHT EMITTING DEVICE CRY1, ORC3, ODC1 SIRT2 2048/4885SIRT1 1465/4885TSHR 4641/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.