Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TLR4 | O00206 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 1/20 | 0.46 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4397448 | 0.85 | TSHR (0.63) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL10972329 | 0.85 | MAPT (0.59) | TSHRCYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL24305918 | 0.84 | MAPK1 (0.55) | TSHRCYP1A2CYP2C9CYP2C19LTA4H | |
| SCHEMBL20432126 | 0.83 | TSHR (0.50) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL2429378 | 0.83 | L3MBTL1 (0.66) | LTA4HL3MBTL1ALDH1A1CACNA1BFAAH | |
| SCHEMBL13349815 | 0.81 | PLA2G4B (0.49) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| 1-Butyloxy-3-Propoxybenzene SCHEMBL3390925 | 0.81 | TSHR (0.59) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL14613207 | 0.81 | LTA4H (0.56) | TSHRLTA4HL3MBTL1ALDH1A1FAAH | |
| SCHEMBL2494479 | 0.80 | MAOB (0.53) | TSHRCYP2C19L3MBTL1ALDH1A1MAPT | |
| SCHEMBL9487103 | 0.80 | LTA4H (0.68) | TSHRCYP1A2CYP19A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230125494-A1 | SYNTHESIS OF NOVEL EP4 ANTAGONIST AND USE IN CANCER AND INFLAMMATION | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230125494-A1 | SYNTHESIS OF NOVEL EP4 ANTAGONIST AND USE IN CANCER AND INFLAMMATION | PTGER4, PTGER3, PTGER2 | TSHR 564/4885CYP1A2 395/4885CYP19A1 2275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.