Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 10/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.51 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26417471 | 0.84 | MAPT (0.69) | TRPV1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL26417399 | 0.83 | MEN1 (0.61) | TRPV1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL26417447 | 0.83 | TRPV1 (0.63) | TRPV1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL26417519 | 0.81 | TAAR1 (0.63) | TRPV1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL22648464 | 0.80 | MEN1 (0.57) | TRPV1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL22648463 | 0.80 | MEN1 (0.57) | TRPV1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL27193042 | 0.80 | RAB9A (0.79) | MEN1KMT2ARAB9AMAPTTAAR1 | |
| SCHEMBL30851500 | 0.80 | RAB9A (0.79) | MEN1KMT2ARAB9AMAPTTAAR1 | |
| SCHEMBL17929425 | 0.77 | SMN1; SMN2 (0.59) | TRPV1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL23831937 | 0.76 | MEN1 (0.80) | TRPV1MEN1KMT2ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675858-B1 | IMIDAZO[1,5-A]PYRAZINE COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | OPTIKIRA LLC (US) | 2023-04-26 | — | — | EP | disclosed |