Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26417507 | 0.86 | TAAR1 (0.60) | TAAR1TRPV1LMNARAB9ANPC1 | |
| SCHEMBL22648623 | 0.83 | TAAR1 (0.56) | TAAR1TRPV1LMNARAB9ANPC1 | |
| SCHEMBL26417409 | 0.81 | TRPV1 (0.61) | TAAR1TRPV1LMNARAB9ANPC1 | |
| SCHEMBL22926673 | 0.78 | TAAR1 (1.00) | TAAR1LMNARAB9ANPC1CYP1A2 | |
| SCHEMBL30851500 | 0.73 | RAB9A (0.79) | TAAR1LMNARAB9ANPC1CYP1A2 | |
| SCHEMBL27193042 | 0.73 | RAB9A (0.79) | TAAR1LMNARAB9ANPC1CYP1A2 | |
| SCHEMBL22926423 | 0.71 | HTT (0.70) | TAAR1LMNARAB9ANPC1MEN1 | |
| SCHEMBL10524065 | 0.71 | RAB9A (0.62) | TAAR1LMNARAB9ANPC1CYP1A2 | |
| SCHEMBL17929425 | 0.70 | SMN1; SMN2 (0.59) | TRPV1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL11100325 | 0.69 | TAAR1 (0.71) | TAAR1LMNARAB9ANPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675858-B1 | IMIDAZO[1,5-A]PYRAZINE COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | OPTIKIRA LLC (US) | 2023-04-26 | — | — | EP | disclosed |