Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 3/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.45 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 2/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11238658 | 0.82 | KEAP1 (0.53) | KEAP1NFE2L2PTGS1PTGS2L3MBTL1 | |
| SCHEMBL2318350 | 0.82 | PTGS1 (0.61) | KEAP1NFE2L2PTGS1PTGS2L3MBTL1 | |
| SCHEMBL12990378 | 0.81 | KEAP1 (0.67) | KEAP1NFE2L2PTGS1PTGS2ALDH1A1 | |
| SCHEMBL3785060 | 0.81 | KEAP1 (0.52) | KEAP1NFE2L2PTGS1PTGS2L3MBTL1 | |
| SCHEMBL3789124 | 0.79 | KEAP1 (0.59) | KEAP1NFE2L2PTGS1PTGS2L3MBTL1 | |
| SCHEMBL8607546 | 0.79 | KEAP1 (0.50) | KEAP1NFE2L2PTGS1PTGS2L3MBTL1 | |
| SCHEMBL2642445 | 0.79 | KEAP1 (0.50) | KEAP1NFE2L2PTGS1PTGS2L3MBTL1 | |
| SCHEMBL2642081 | 0.79 | KEAP1 (0.50) | KEAP1NFE2L2PTGS1PTGS2L3MBTL1 | |
| SCHEMBL30505727 | 0.78 | ALDH1A1 (0.55) | KEAP1NFE2L2PTGS1PTGS2L3MBTL1 | |
| SCHEMBL13145656 | 0.77 | KEAP1 (0.47) | KEAP1NFE2L2PTGS1PTGS2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687502-B2 | Substituted quinazoline or pyridopyrimidine derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-20080032996-A1 | Substituted Quinazoline or Pyridopyrimidine Derivative | MSD K.K. (JP) | 2008-02-07 | — | — | US | disclosed |
| EP-1734040-A1 | SUBSTITUTED QUINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-12-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032996-A1 | Substituted Quinazoline or Pyridopyrimidine Derivative | GCK, GCKR, PDXK | KEAP1 954/4885NFE2L2 406/4885PTGS1 1687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.