Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.59 |
| ▸ | CES1 | P23141 | 4/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16861562 | 0.88 | CES2 (0.50) | CES2CES1BCHEHPGDHSD11B1 | |
| Hydrochloric Acid SCHEMBL15565860 | 0.87 | CES2 (0.49) | CES2CES1BCHEHPGDHSD11B1 | |
| SCHEMBL718095 | 0.84 | CES2 (0.56) | CES2CES1HPGDPDK2HSD11B1 | |
| SCHEMBL29591363 | 0.84 | CES2 (0.56) | CES2CES1HPGDPDK2HSD11B1 | |
| SCHEMBL2642208 | 0.83 | ALB (0.58) | CES2CES1BCHEHPGDPDK2 | |
| SCHEMBL2642205 | 0.83 | CES2 (0.42) | CES2CES1BCHEHPGDPDK2 | |
| SCHEMBL8060836 | 0.81 | HSD11B1 (0.46) | HPGDPDK2HSD11B1HTR1FRIPK1 | |
| SCHEMBL14831804 | 0.81 | PDK2 (0.41) | CES2CES1BCHEPDK2HSD11B1 | |
| SCHEMBL9274620 | 0.81 | HSD11B1 (0.41) | CES2CES1BCHEHPGDPDK2 | |
| SCHEMBL15587991 | 0.81 | ESR1 (0.46) | CES2CES1BCHEPDK2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103922904-A | Method for synthesizing 2-fluoroarylcarbonyl compounds | UNIV ZHEJIANG TECHNOLOGY | 2014-07-16 | — | — | CN | disclosed |
| US-7687502-B2 | Substituted quinazoline or pyridopyrimidine derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-20080032996-A1 | Substituted Quinazoline or Pyridopyrimidine Derivative | MSD K.K. (JP) | 2008-02-07 | — | — | US | disclosed |
| EP-1734040-A1 | SUBSTITUTED QUINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-12-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080032996-A1 | Substituted Quinazoline or Pyridopyrimidine Derivative | GCK, GCKR, PDXK | CES2 2078/4885CES1 1793/4885BCHE 2373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.