Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26090436 | 1.00 | RAB9A (0.51) | RAB9AHTTNPC1MAPTMAPK1 | |
| SCHEMBL26136542 | 0.84 | HTT (0.48) | RAB9AHTTNPC1MAPTMAPK1 | |
| SCHEMBL30407845 | 0.84 | HTT (0.48) | RAB9AHTTNPC1MAPTMAPK1 | |
| SCHEMBL26136718 | 0.82 | MAOB (0.47) | RAB9AHTTNPC1DHFRSMPD1 | |
| SCHEMBL30407694 | 0.82 | MAOB (0.47) | RAB9AHTTNPC1DHFRSMPD1 | |
| SCHEMBL26425656 | 0.79 | NPC1 (0.54) | RAB9AHTTNPC1MAPTMAPK1 | |
| SCHEMBL26090397 | 0.77 | NPC1 (0.63) | RAB9AHTTNPC1MAPTMAPK1 | |
| SCHEMBL26090239 | 0.77 | HTT (0.63) | RAB9AHTTNPC1MAPTMAPK1 | |
| SCHEMBL29244971 | 0.77 | DHFR (0.43) | RAB9AMAPK1DHFRMAOBMEN1 | |
| SCHEMBL3423658 | 0.77 | MAOB (0.65) | RAB9AMAPK1DHFRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4419508-A2 | OXAZOLE, OXADIAZOLE, AND INDOLE DERIVATIVES FOR THE INHIBITION OF USP28 | Carmot Therapeutics, Inc. (US) | 2024-08-28 | — | — | EP | disclosed |
| WO-2023069721-A2 | OXAZOLE, OXADIAZOLE, AND INDOLE DERIVATIVES FOR THE INHIBITION OF USP28 | CARMOT THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |