Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 12/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26419960 | 0.75 | LMNA (0.39) | LMNAPOLBKLKB1DGAT1 | |
| SCHEMBL21408586 | 0.67 | LMNA (0.39) | LMNAPOLBKLKB1DGAT1 | |
| SCHEMBL15328476 | 0.65 | LMNA (0.58) | LMNAPOLBCNR1HTT | |
| SCHEMBL21408550 | 0.64 | KDM2B (0.36) | LMNAPOLBKLKB1KLK1HTT | |
| SCHEMBL18396686 | 0.64 | MEN1 (0.43) | LMNAPOLBCNR1HTT | |
| SCHEMBL26389004 | 0.64 | — | — | |
| SCHEMBL22847893 | 0.64 | POLB (0.60) | LMNAPOLBKLKB1CNR1DGAT1 | |
| SCHEMBL3901793 | 0.63 | GAA (0.43) | LMNAPOLBHTTDGAT1 | |
| SCHEMBL9017973 | 0.63 | POLB (0.51) | LMNAPOLBCNR1HTT | |
| SCHEMBL26419959 | 0.63 | KLKB1 (0.43) | LMNAPOLBKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |