Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 4/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26135704 | 0.83 | ADORA3 (0.36) | KLKB1IRAK4ADORA3 | |
| SCHEMBL12092481 | 0.78 | GAA (0.43) | KLKB1GAAMAP2K2MAP2K1LMNA | |
| SCHEMBL26388999 | 0.73 | — | — | |
| SCHEMBL26135903 | 0.72 | ADORA3 (0.36) | KLKB1ADORA3 | |
| SCHEMBL26420142 | 0.70 | LMNA (0.39) | KLKB1LMNAPOLBALDH1A1ADORA3 | |
| SCHEMBL26406187 | 0.70 | ADORA3 (0.41) | KLKB1LMNAALDH1A1ADORA3ADORA2A | |
| SCHEMBL12057438 | 0.69 | POLB (0.42) | KLKB1LMNAPOLBIRAK4 | |
| SCHEMBL26406052 | 0.67 | ADORA3 (0.38) | KLKB1LMNAALDH1A1ADORA3ADORA2A | |
| SCHEMBL18330041 | 0.66 | KLKB1 (0.39) | KLKB1GAALMNAPOLBALDH1A1 | |
| SCHEMBL1871681 | 0.66 | L3MBTL1 (0.40) | KLKB1GAALMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |