Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25876684 | 0.76 | GRIN1 (0.33) | NEK2 | |
| SCHEMBL19851165 | 0.76 | OTUD7B (0.36) | NEK2 | |
| SCHEMBL25876593 | 0.76 | NEK2 (0.31) | NEK2ALDH1A1 | |
| SCHEMBL19851182 | 0.74 | NEK2 (0.30) | NEK2 | |
| SCHEMBL19839183 | 0.74 | NEK2 (0.30) | NEK2 | |
| SCHEMBL25876681 | 0.74 | OPRM1 (0.31) | NEK2 | |
| SCHEMBL14388348 | 0.67 | NEK2 (0.35) | NEK2 | |
| SCHEMBL12028806 | 0.67 | — | — | |
| SCHEMBL12405084 | 0.67 | ALDH1A1 (0.31) | NEK2ALDH1A1MAPK1 | |
| SCHEMBL33525605 | 0.66 | ALDH1A1 (0.32) | ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230131402-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC (US) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230131402-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | GRIN1, GRIN2A, GRIN3A | NEK2 884/4885ALDH1A1 2489/4885MAPK1 3643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.