Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26427463 | 0.82 | MAPK1 (0.40) | MAPK1KDM4EPKMUSP30MEN1 | |
| SCHEMBL26427489 | 0.79 | MEN1 (0.42) | MAPK1KDM4EPKMUSP30MEN1 | |
| SCHEMBL26427482 | 0.79 | KDM4E (0.39) | MAPK1KDM4EPKMUSP30MEN1 | |
| SCHEMBL26427476 | 0.79 | KDM4E (0.39) | MAPK1KDM4EPKMUSP30MEN1 | |
| SCHEMBL26093055 | 0.77 | OPRD1 (0.44) | MAPK1KDM4EPKMGPR119RORC | |
| SCHEMBL26093708 | 0.74 | MEN1 (0.45) | MAPK1MEN1KMT2A | |
| SCHEMBL26093108 | 0.74 | USP2 (0.39) | MAPK1KDM4EGPR119 | |
| SCHEMBL30485067 | 0.73 | SOS1 (0.44) | MAPK1KDM4E | |
| SCHEMBL20019676 | 0.72 | KDM4E (0.43) | KDM4EPKMUSP30MEN1KMT2A | |
| SCHEMBL29395081 | 0.72 | OPRD1 (0.46) | MAPK1USP30GPR119RORCSCD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023067354-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023067353-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2023-04-27 | — | — | WO | disclosed |