Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26427466 | 0.82 | MAPK1 (0.43) | MAPK1KDM4EPKMUSP30MEN1 | |
| SCHEMBL26136524 | 0.76 | NR1H2 (0.38) | MAPK1KDM4EUSP30CRBNGPR119 | |
| SCHEMBL26089899 | 0.75 | NR1H2 (0.41) | MAPK1KDM4ECRBNGPR119DDB1 | |
| SCHEMBL26090531 | 0.75 | NPC1 (0.43) | MAPK1MEN1KMT2ACRBNDDB1 | |
| SCHEMBL26427482 | 0.74 | KDM4E (0.39) | MAPK1KDM4EPKMUSP30MEN1 | |
| SCHEMBL26427476 | 0.74 | KDM4E (0.39) | MAPK1KDM4EPKMUSP30MEN1 | |
| SCHEMBL26427489 | 0.72 | MEN1 (0.42) | MAPK1KDM4EPKMUSP30MEN1 | |
| SCHEMBL26427522 | 0.70 | KDM4E (0.40) | KDM4EPKMUSP30MEN1KMT2A | |
| SCHEMBL30485035 | 0.70 | TSHR (0.40) | MAPK1KMT2ACRBNDDB1TSHR | |
| SCHEMBL25770784 | 0.69 | KDM4E (0.44) | MAPK1KDM4EPKMUSP30MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023067354-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023067353-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ARTIOS PHARMA LIMITED (GB) | 2023-04-27 | — | — | WO | disclosed |